{"created":"2023-05-15T09:47:27.536348+00:00","id":9544,"links":{},"metadata":{"_buckets":{"deposit":"e58e044b-3e0e-4b19-ab81-0e35e4444cfc"},"_deposit":{"created_by":11,"id":"9544","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"9544"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00009544","sets":["13:40"]},"author_link":["3479"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"線維芽細胞増殖因子徐放ゼラチンシートによる肺気腫肺の再生","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Basic fibroblast growth factor (bFGF) induces regeneration and neovascularization of the lungs. We conducted this study to demonstrate the regeneration of emphysematous lungs achieved by gelatin sheets that slowly release bFGF into the visceral pleura in a canine model.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Methods: Porcine pancreatic elastase was used to induce bilateral lower lobe pulmonary emphysema in dogs. Slow-release bFGF gelatin sheets were attached to the visceral pleura of the left lower lobe via thoracotomy. The subjects were divided into two groups: one treated with gelatin sheets containing slow-release bFGF (bFGF+ group, n = 5), and the other, treated with only gelatin sheets (bFGF- group, n = 5). The subjects were euthanized after 28 days and histologic lung assessment was performed. The results were evaluated in terms of the mean linear intercept (MLI) and microvessel count.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: The MLI was significantly shorter in the bFGF+ group than in the bFGF- group; (110.0 ± 24.38 vs. 208.9 ± 33.08 μm; P = 0.0006). The microvessel count was not significantly different between the bFGF+ and bFGF- groups (12.20 ± 3.007 vs. 5.35 ± 2.3425; P = 0.075); however, it was significantly higher in the bFGF-attached lungs than in the emphysema group (12.20 ± 3.007 vs. 4.57 ± 0.8896; P = 0.012).","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions: Attaching gelatin sheets with slow-release bFGF to the visceral pleura induced lung regeneration and vascularization in a canine pulmonary emphysema model.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第793号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00595-022-02465-z","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"35122522","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.","subitem_rights_language":"en"},{"subitem_rights":"Embergo expiration date: 2023-02-05","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大月, 康弘","creatorNameLang":"ja"},{"creatorName":"オオツキ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Otsuki, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-05"}],"displaytype":"detail","filename":"Med_A793.pdf","filesize":[{"value":"419.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/9544/files/Med_A793.pdf"},"version_id":"228e479f-2a95-448c-98e8-f7d6baee532c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-20"}],"displaytype":"detail","filename":"Med_A793_abstract.pdf","filesize":[{"value":"84.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/9544/files/Med_A793_abstract.pdf"},"version_id":"74ba0638-a393-4584-94c9-16d678efc93c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-20"}],"displaytype":"detail","filename":"Med_A793_result.pdf","filesize":[{"value":"81.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/9544/files/Med_A793_result.pdf"},"version_id":"a2644e5d-8aaf-48f0-8b9a-b0fbf5dc9c59"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Lung regeneration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Basic fibroblast growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Emphysema","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chronic obstructive lung disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Canine model","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Regeneration of emphysematous lungs using gelatin sheets that release basic fibroblast growth factor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regeneration of emphysematous lungs using gelatin sheets that release basic fibroblast growth factor","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-20"},"publish_date":"2022-04-20","publish_status":"0","recid":"9544","relation_version_is_last":true,"title":["Regeneration of emphysematous lungs using gelatin sheets that release basic fibroblast growth factor"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-10-16T02:31:10.489620+00:00"}