{"created":"2023-05-15T09:47:27.578561+00:00","id":9545,"links":{},"metadata":{"_buckets":{"deposit":"4ec10aee-98b3-4656-8d14-91c950f086b6"},"_deposit":{"created_by":11,"id":"9545","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"9545"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00009545","sets":["13:40"]},"author_link":["3480"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ガレクチン9の欠損はリポポリサッカライドによる低体温と腎障害を増悪させる","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Galectin-9 (Gal-9) is a multifunctional lectin that moderates inflammation and organ damage. In this study, we tested whether Gal-9 has a protective role in the pathogenesis of endotoxemic acute kidney injury.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Methods: We examined the levels of Gal-9 in control mice after lipopolysaccharide (LPS) administration. We developed Gal-9 knockout (KO) mice that lack Gal-9 systemically and evaluated the role of Gal-9 in LPS-induced proinflammatory cytokines, vascular permeability, and renal injury.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: Gal-9 levels were increased in the plasma, kidney, and spleen within 4 h after LPS administration to wild-type mice. Gal-9 deficiency did not affect the LPS-induced increase in plasma tumor necrosis factor-α levels at 1 h or vascular permeability at 6 h. Lower urine volume and reduced creatinine clearance were observed in Gal-9-KO mice compared with wild-type mice after LPS administration. Gal-9-KO mice had limited improvement in urine volume after fluid resuscitation compared with wild-type mice. LPS reduced the body temperature 12 h after its administration. Hypothermia had disappeared in wild-type mice by 24 h, whereas it was sustained until 24 h in Gal-9-KO mice. Importantly, maintaining body temperature in Gal-9-KO mice improved the response of urine flow to fluid resuscitation.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion: Deficiency in Gal-9 worsened LPS-induced hypothermia and kidney injury in mice. The accelerated hypothermia induced by Gal-9 deficiency contributed to the blunted response to fluid resuscitation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第794号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10157-021-02152-2","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34698914","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 Springer Nature Switzerland AG. Part of Springer Nature.","subitem_rights_language":"en"},{"subitem_rights":"Embergo expiration date: 2022-10-26","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大西, 啓右","creatorNameLang":"ja"},{"creatorName":"オオニシ, ケイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Onishi, Keisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3480","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000403546635","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000403546635"},{"nameIdentifier":"60801397","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60801397"},{"nameIdentifier":"onishi-keisuke","nameIdentifierScheme":"researchmap","nameIdentifierURI":"https://researchmap.jp/onishi-keisuke"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-26"}],"displaytype":"detail","filename":"Med_A794.pdf","filesize":[{"value":"4.4 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/9545/files/Med_A794.pdf"},"version_id":"85d544bf-dad7-4a56-816c-43fd0a7f3031"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-20"}],"displaytype":"detail","filename":"Med_A794_abstract.pdf","filesize":[{"value":"63.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/9545/files/Med_A794_abstract.pdf"},"version_id":"492e9488-5e38-4826-96cd-73b3dde7952d"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-20"}],"displaytype":"detail","filename":"Med_A794_result.pdf","filesize":[{"value":"85.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/9545/files/Med_A794_result.pdf"},"version_id":"42563357-0370-46a8-b491-4f486e923fc0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Lipopolysaccharide (LPS)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Acute kidney injury (AKI)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Galectin-9","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hypothermia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Galectin-9 deficiency exacerbates lipopolysaccharide-induced hypothermia and kidney injury","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Galectin-9 deficiency exacerbates lipopolysaccharide-induced hypothermia and kidney injury","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-20"},"publish_date":"2022-04-20","publish_status":"0","recid":"9545","relation_version_is_last":true,"title":["Galectin-9 deficiency exacerbates lipopolysaccharide-induced hypothermia and kidney injury"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T07:58:39.684561+00:00"}