{"created":"2023-05-15T09:47:27.955697+00:00","id":9555,"links":{},"metadata":{"_buckets":{"deposit":"1dc862a7-4226-49e1-94cc-f4f150f3ceff"},"_deposit":{"created_by":11,"id":"9555","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"9555"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00009555","sets":["13:40"]},"author_link":["3487"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"消化器系統癌細胞株を用いたTERTプロモーター点変異の網羅的解析","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/aim: The promoter region of the telomerase reverse transcriptase (TERT) gene is a regulatory element capable of affecting TERT expression, telomerase activity, and telomerase length. Mutations within the TERT promoter region are the most common mutations in many cancers. In this study, we characterized the TERT promoter mutation status in hepatobiliary, pancreatic, and gastrointestinal cancer cell lines.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Materials and methods: TERT promoter mutation status was assessed by digital PCR in 12 liver cancer, 5 cholangiocarcinoma (CCA), 12 pancreatic cancer, 17 gastrointestinal cancer, and 3 healthy control cell lines.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: The C228T promoter mutation was detected in 9 liver cancer lines, and the C250T TERT mutation was detected in 1 oesophageal squamous cell carcinoma line.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion: The C228T promoter mutation is specific to liver cancer cell lines among various gastrointestinal cancer cell lines. These data will contribute to future research on the tumorigenic mechanisms and clinical use of digital PCR to detect mutations.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第803号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.21873/invivo.12680","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"hasVersion","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8765179/","subitem_relation_type_select":"URI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34972704","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.","subitem_rights_language":"en"},{"subitem_rights":"This article is freely accessible online.","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAlternatives":[{"creatorAlternative":"平田, 正大","creatorAlternativeLang":"ja"},{"creatorAlternative":"ヒラタ, マサヒロ","creatorAlternativeLang":"ja-Kana"},{"creatorAlternative":"Hirata, Masahiro","creatorAlternativeLang":"en"}],"creatorNames":[{"creatorName":"小野, 正大","creatorNameLang":"ja"},{"creatorName":"オノ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Ono, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3487","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-21"}],"displaytype":"detail","filename":"Med_A803.pdf","filesize":[{"value":"497.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/9555/files/Med_A803.pdf"},"version_id":"206cfa41-e518-493e-ae1d-b7920d6d1649"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-21"}],"displaytype":"detail","filename":"Med_A803_abstract.pdf","filesize":[{"value":"79.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/9555/files/Med_A803_abstract.pdf"},"version_id":"6b3bbf52-3c95-4ca0-9247-d46ac885629a"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-21"}],"displaytype":"detail","filename":"Med_A803_result.pdf","filesize":[{"value":"141.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/9555/files/Med_A803_result.pdf"},"version_id":"c680e6cf-9225-4363-80d1-9ff61ad1836a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"TERT","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"telomerase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatobiliary","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gastrointestinal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"digital PCR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TERT promoter C228T","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TERT promoter C250T","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Telomerase reverse transcriptase promoter mutations in human hepatobiliary, pancreatic and gastrointestinal cancer cell lines","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Telomerase reverse transcriptase promoter mutations in human hepatobiliary, pancreatic and gastrointestinal cancer cell lines","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-21"},"publish_date":"2022-04-21","publish_status":"0","recid":"9555","relation_version_is_last":true,"title":["Telomerase reverse transcriptase promoter mutations in human hepatobiliary, pancreatic and gastrointestinal cancer cell lines"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T08:01:42.323177+00:00"}