{"created":"2023-05-15T09:47:28.164810+00:00","id":9560,"links":{},"metadata":{"_buckets":{"deposit":"c5f404b9-664d-4e8e-88f6-7d5d141741cb"},"_deposit":{"created_by":11,"id":"9560","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"9560"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00009560","sets":["13:40"]},"author_link":["3492"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"肺腺癌切除症例において腫瘍関連マクロファージは肺癌の気腔内進展と関連している","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: Lung cancer can spread in numerous ways, one of which has been suggested to be spread through air spaces (STAS). The tumor immune microenvironment appears to play a significant role in this spread. Particularly, tumor-associated macrophages (TAMs) can create a favorable microenvironment for tumor progression. In this study, we analyzed data from 709 patients with stage 0-IIIA lung adenocarcinoma, resected between 1999 and 2016, and investigated whether immune cell infiltration was associated with the occurrence of STAS and clinical outcome of the disease.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Materials and methods: Tissue microarrays were constructed, and immunohistochemical analysis was performed for CD3, CD4, CD8, CD45RO, CD25, CD20, and CD68. The three tumor areas with the highest density of immune cells were photographed, and the immune cells were quantified. Associations between variables were analyzed using chi-square tests and Mann-Whitney U tests. Recurrence-free probability and overall survival were analyzed using log-rank tests and Cox proportional hazards models.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: After analyzing the associations between STAS and each type of immune cell infiltration, high density of CD68 + TAMs was identified as an independent predictor of a high STAS rate (p =  0.014) and was found to be associated with a high risk of recurrence, using univariate analysis (p =  0.008). After adjusting for CD68+ TAMs, pathological stage, and lymphovascular invasion, STAS remained significantly associated with a high risk of recurrence (HR = 3.50, p < 0.001).","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion: We demonstrated that a high density of CD68 + TAMs is an independent predictor of an increased STAS rate. Additionally, STAS is correlated with aggressive tumor behavior characteristics.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第808号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.lungcan.2021.06.009","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34139640","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 Elsevier B.V. All rights reserved.","subitem_rights_language":"en"},{"subitem_rights":"Embergo expiration date: 2022-06-10","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉田, 千尋","creatorNameLang":"ja"},{"creatorName":"ヨシダ, チヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshida, Chihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-10"}],"displaytype":"detail","filename":"Med_A808.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/9560/files/Med_A808.pdf"},"version_id":"6d9374e7-38aa-4fea-b799-88f2da125f20"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-22"}],"displaytype":"detail","filename":"Med_A808_abstract.pdf","filesize":[{"value":"897.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/9560/files/Med_A808_abstract.pdf"},"version_id":"b26eeb02-1101-420c-99e7-5ed254c59474"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-22"}],"displaytype":"detail","filename":"Med_A808_result.pdf","filesize":[{"value":"91.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/9560/files/Med_A808_result.pdf"},"version_id":"ca04ece0-286f-41fe-8295-19da0cf72f55"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD68+ TAM","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor immune microenvironment","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immune cell infiltration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Risk of recurrence","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aggressive tumor behavior","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Tumor-associated macrophage infiltration is associated with a higher rate of tumor spread through air spaces in resected lung adenocarcinomas.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tumor-associated macrophage infiltration is associated with a higher rate of tumor spread through air spaces in resected lung adenocarcinomas.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-22"},"publish_date":"2022-04-22","publish_status":"0","recid":"9560","relation_version_is_last":true,"title":["Tumor-associated macrophage infiltration is associated with a higher rate of tumor spread through air spaces in resected lung adenocarcinomas."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-10-16T02:31:54.923125+00:00"}