{"created":"2023-05-15T09:47:38.258760+00:00","id":9798,"links":{},"metadata":{"_buckets":{"deposit":"59ec515e-8cf3-4451-ad92-455caadb3f01"},"_deposit":{"created_by":11,"id":"9798","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"9798"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00009798","sets":["13:40"]},"author_link":["3705"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ゾレドロン酸とデノスマブが顎骨やその他の正常骨に与える影響〜¹⁸F‐NaF‐PETによる検討〜","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-06-15"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: The primary purpose of this study was to determine whether both zoledronic acid (ZA) and denosumab (Dmab) equally suppress bone remodeling of the normal mandible, and the secondary purpose was to determine the influence of ZA and Dmab on other normal bones.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Methods: 18F-sodium fluoride-positron-emission-tomography (18F-NaF-PET) was used to perform quantitative analysis of the bone metabolism in various parts. The end points of the study were the mean standardized uptake value (SUV) of each member of the ZA group (n = 9), the Dmab group (n = 16), and the Control group (n = 23).","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: The SUV at the thoracic vertebrae in the ZA group were significantly lower than those of the Dmab and Control group (p < 0.05) In addition, the mean SUVs of the cervical vertebrae in the ZA group were significantly lower than those in the Control group (p < 0.05). There was no significant difference among ZA, Dmab and Control group in the other sites. There was no significant difference between the Dmab and Control groups at all sites.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions: The remodeling of mandible was not suppressed due to the treatment with anti-resorptive agents. Differences in the mechanisms of action between the BP and Dmab caused the specificity of the effect on the metabolism of normal bone.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第298号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s11282-022-00594-2","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"35142984","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022. The Author(s) under exclusive licence to Japanese Society for Oral and Maxillofacial Radiology.","subitem_rights_language":"en"},{"subitem_rights":"© 2022 Springer Nature Switzerland AG. Part of Springer Nature.","subitem_rights_language":"en"},{"subitem_rights":"Embergo expiration date: 2023-02-10","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伏見, 麻央","creatorNameLang":"ja"},{"creatorName":"フシミ, マオ","creatorNameLang":"ja-Kana"},{"creatorName":"Fushimi, Mao","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-10"}],"displaytype":"detail","filename":"Med_B298.pdf","filesize":[{"value":"194.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/9798/files/Med_B298.pdf"},"version_id":"9325db90-f8a0-4f20-8bd3-453162fff8a9"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-07"}],"displaytype":"detail","filename":"Med_B298_abstract.pdf","filesize":[{"value":"80.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/9798/files/Med_B298_abstract.pdf"},"version_id":"c8ddef06-2e37-4138-ab9c-e914ef2823a1"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-07"}],"displaytype":"detail","filename":"Med_B298_result.pdf","filesize":[{"value":"64.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/9798/files/Med_B298_result.pdf"},"version_id":"984435d8-33b4-4705-a261-edcb37cbb900"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Osteonecrosis of jaw","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone metabolism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bisphosphonate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Denosumab","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"18F-NaF-PET","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The effect of zoledronic acid and denosumab on the mandible and other bones : a ¹⁸F‐NaF‐PET study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The effect of zoledronic acid and denosumab on the mandible and other bones : a ¹⁸F‐NaF‐PET study","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-07-07"},"publish_date":"2022-07-07","publish_status":"0","recid":"9798","relation_version_is_last":true,"title":["The effect of zoledronic acid and denosumab on the mandible and other bones : a ¹⁸F‐NaF‐PET study"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-10-16T02:32:08.215806+00:00"}