{"created":"2023-05-15T09:47:38.301249+00:00","id":9799,"links":{},"metadata":{"_buckets":{"deposit":"e98445bb-8133-435f-bb7b-efe255e80f79"},"_deposit":{"created_by":11,"id":"9799","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"9799"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00009799","sets":["13:40"]},"author_link":["3706"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"レンバチニブ耐性肝細胞癌におけるシスプラチン作用の特性","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-06-29"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/aim: Drug resistance to molecular targeted agents, such as lenvatinib, is an important issue. The aim of this study was to explore the mechanism of lenvatinib resistance and to investigate potential drugs that may improve the treatment of lenvatinib-resistant (LR) hepatocellular carcinoma (HCC).","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Materials and methods: LR cells were developed by long-term culture under lenvatinib exposure. We analyzed the biological characteristics of LR cells in vitro, and investigated the antitumor effects and endogenous mechanisms of cisplatin in LR cells.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: The proliferative potential of LR cells was enhanced by activation of ERK signaling and changes in several miRNAs. Cisplatin inhibited cell proliferation of LR cells and induced G2/M cell cycle arrest. Furthermore, cisplatin triggered the DNA damage response, via the ATM/ATR-Chk1/Chk2 signaling pathway.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion: Proliferation of LR cells was induced upon ERK signaling activation. Cisplatin exerted antitumor effects in LR cells and was involved in the regulation of miRNAs associated with drug resistance.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第811号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.21873/anticanres.15593","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"35220216","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"濱谷, 紗江","creatorNameLang":"ja"},{"creatorName":"ハマヤ, サエ","creatorNameLang":"ja-Kana"},{"creatorName":"Hamaya, Sae","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3706","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000319049866","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000319049866"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-09"}],"displaytype":"detail","filename":"Med_A811_summary.pdf","filesize":[{"value":"252.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文の要約","objectType":"summary","url":"https://kagawa-u.repo.nii.ac.jp/record/9799/files/Med_A811_summary.pdf"},"version_id":"8dd92b1e-008d-4c39-8cf6-cfad8d04c131"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-07"}],"displaytype":"detail","filename":"Med_A811_abstract.pdf","filesize":[{"value":"138.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/9799/files/Med_A811_abstract.pdf"},"version_id":"5eccedce-6f90-4b70-9c67-fd6fda3a2f2c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-07"}],"displaytype":"detail","filename":"Med_A811_result.pdf","filesize":[{"value":"103.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/9799/files/Med_A811_result.pdf"},"version_id":"ef467350-1cbf-42b6-b8ac-fadab44b9840"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hepatocellular carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lenvatinib resistance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cisplatin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell cycle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Characterization of cisplatin effects in lenvatinib‐resistant hepatocellular carcinoma cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Characterization of cisplatin effects in lenvatinib‐resistant hepatocellular carcinoma cells","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-07-07"},"publish_date":"2022-07-07","publish_status":"0","recid":"9799","relation_version_is_last":true,"title":["Characterization of cisplatin effects in lenvatinib‐resistant hepatocellular carcinoma cells"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T07:58:38.671532+00:00"}