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Correlation of 18F-fluoromisonidazole PET findings with HIF-1α and p53 expressions in head and neck cancer : comparison with 18F-FDG PET
https://kagawa-u.repo.nii.ac.jp/records/201
https://kagawa-u.repo.nii.ac.jp/records/20195f7ed03-0ec9-4fe5-adea-97b4a7d17ca4
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内容の要旨 (332.3 kB)
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審査の結果の要旨 (327.5 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||||
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| 公開日 | 2014-03-24 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Correlation of 18F-fluoromisonidazole PET findings with HIF-1α and p53 expressions in head and neck cancer : comparison with 18F-FDG PET | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||||
| 資源タイプ | doctoral thesis | |||||||||||||
| 著者 |
則兼, 敬志
× 則兼, 敬志
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Objective We evaluated tumor hypoxia using 18F-fluoromisonidazole (18F-FMISO) PET in relation to the expression of hypoxia-inducible factor-1α (HIF-1α) and p53 in patients with head and neck cancer and compared the results with those obtained using 2-deoxy-2-18F-fluoro-D-glucose (18F-FDG) PET. |
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| 言語 | en | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Materials and methods A total of 28 tumors (23 primary tumors and five metastatic lymph nodes) from 24 patients with newly diagnosed head and neck cancer were examined with 18F-FMISO PET and 18F-FDG PET. The 18F-FMISO PET images were scaled to the venous blood concentration of 18F-FMISO activity to produce tumor-to-blood (T/B) values. Hypoxia was defined as a region with a T/B ratio greater than or equal to 1.2. The maximum T/B (T/Bmax) and hypoxic volumes were calculated by region-of-interest analysis. For 18F-FDG PET, the maximum standardized uptake value (SUVmax) and hypermetabolic volume were calculated by region-of-interest analysis. The expressions of HIF-1α and p53 using immunohistochemistry were estimated in tumor tissue samples. |
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| 言語 | en | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Results A weak correlation was observed between hypoxic volume and T/Bmax (r=0.53, P=0.003) on using 18F-FMISO PET and between hypermetabolic volume and SUVmax (r=0.38, P=0.046) on using 18F-FDG PET. The hypoxic volume using 18F-FMISO PET and hypermetabolic volume using 18F-FDG PET also showed a weak correlation (r=0.44, P=0.020). The values of 18F-FMISO hypoxic volume showed a weak correlation with HIF-1α (r=0.40, P=0.037) and p53 (r=0.47, P=0.012) obtained on immunohistochemical examination. |
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| 言語 | en | |||||||||||||
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| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Conclusion This study demonstrates a weak correlation between hypoxic volume measured by 18F-FMISO PET and expressions of HIF-1α and p53 in head and neck cancer. |
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| 言語 | en | |||||||||||||
| 学位名 | ||||||||||||||
| 言語 | ja | |||||||||||||
| 学位名 | 博士（医学） | |||||||||||||
| 学位授与機関 | ||||||||||||||
| 識別子Scheme | kakenhi | |||||||||||||
| 識別子 | 16201 | |||||||||||||
| 言語 | ja | |||||||||||||
| 機関名 | 香川大学 | |||||||||||||
| 言語 | en | |||||||||||||
| 機関名 | Kagawa University | |||||||||||||
| 学位授与年月日 | ||||||||||||||
| 学位授与年月日 | 2014-03-24 | |||||||||||||
| 学位授与番号 | ||||||||||||||
| 学位授与番号 | 甲第586号 | |||||||||||||
| 権利 | ||||||||||||||
| 言語 | en | |||||||||||||
| 権利情報 | © 2014 Wolters Kluwer Health, Lippincott Williams & Wilkins | |||||||||||||
| PubMed番号 | ||||||||||||||
| 識別子タイプ | PMID | |||||||||||||
| 関連識別子 | 24121312 | |||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1097/MNM.0000000000000010 | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | 2-deoxy-2-18F-fluoro-D-glucose | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | 18F-fluoromisonidazole | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | head and neck cancer | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | hypoxia-inducible factor-1α | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | p53 | |||||||||||||
| KEID | ||||||||||||||
| 27469 | ||||||||||||||
