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Comparison of 4′-[methyl-11C]thiothymidine (11C-4DST) and 3′-deoxy-3′-[18F]fluorothymidine (18F-FLT) PET/CT in human brain glioma imaging
https://kagawa-u.repo.nii.ac.jp/records/368
https://kagawa-u.repo.nii.ac.jp/records/368b4af8301-3113-48d3-ab78-d6d4d2987398
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||||
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公開日 | 2019-07-09 | |||||||||||||
タイトル | ||||||||||||||
言語 | en | |||||||||||||
タイトル | Comparison of 4′-[methyl-11C]thiothymidine (11C-4DST) and 3′-deoxy-3′-[18F]fluorothymidine (18F-FLT) PET/CT in human brain glioma imaging | |||||||||||||
言語 | ||||||||||||||
言語 | eng | |||||||||||||
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資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||||
資源タイプ | doctoral thesis | |||||||||||||
アクセス権 | ||||||||||||||
アクセス権 | open access | |||||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
著者 |
豊田, 康則
× 豊田, 康則
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抄録 | ||||||||||||||
内容記述タイプ | Abstract | |||||||||||||
内容記述 | Background: 3'-deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT) has been used to evaluate tumor malignancy and cell proliferation in human brain gliomas. However, (18)F-FLT has several limitations in clinical use. Recently, (11)C-labeled thymidine analogue, 4'-[methyl-(11)C]thiothymidine ((11)C-4DST), became available as an in vivo cell proliferation positron emission tomography (PET) tracer. The present study was conducted to evaluate the usefulness of (11)C-4DST PET in the diagnosis of human brain gliomas by comparing with the images of (18)F-FLT PET. | |||||||||||||
言語 | en | |||||||||||||
抄録 | ||||||||||||||
内容記述タイプ | Abstract | |||||||||||||
内容記述 | Methods: Twenty patients with primary and recurrent brain gliomas underwent (18)F-FLT and (11)C-4DST PET scans. The uptake values in the tumors were evaluated using the maximum standardized uptake value (SUVmax), the tumor-to-normal tissue uptake (T/N) ratio, and the tumor-to-blood uptake (T/B) ratio. These values were compared among different glioma grades. Correlation between the Ki-67 labeling index and the uptake values of (11)C-4DST and (18)F-FLT in the tumor was evaluated using linear regression analysis. The relationship between the individual (18)F-FLT and (11)C-4DST uptake values in the tumors was also examined. | |||||||||||||
言語 | en | |||||||||||||
抄録 | ||||||||||||||
内容記述タイプ | Abstract | |||||||||||||
内容記述 | Results: (11)C-4DST uptake was significantly higher than that of (18)F-FLT in the normal brain. The uptake values of (11)C-4DST in the tumor were similar to those of (18)F-FLT resulting in better visualization with (18)F-FLT. No significant differences in the uptake values of (18)F-FLT and (11)C-4DST were noted among different glioma grades. Linear regression analysis showed a significant correlation between the Ki-67 labeling index and the T/N ratio of (11)C-4DST (r = 0.50, P < 0.05) and (18)F-FLT (r = 0.50, P < 0.05). Significant correlations were also found between the Ki-67 labeling index and the T/B ratio of (11)C-4DST (r = 0.52, P < 0.05) and (18)F-FLT (r = 0.55, P < 0.05). A highly significant correlation was observed between the individual T/N ratio of (11)C-4DST and (18)F-FLT in the tumor (r = 0.79, P = 0.0001). | |||||||||||||
言語 | en | |||||||||||||
抄録 | ||||||||||||||
内容記述タイプ | Abstract | |||||||||||||
内容記述 | Conclusions: The present study demonstrates that (11)C-4DST is useful for the imaging of human brain gliomas with PET. A relatively higher background uptake of (11)C-4DST in the normal brain compared to (18)F-FLT limits the detection of low-tracer-uptake tumors. Moreover, no superiority was found in (11)C-4DST over (18)F-FLT in the evaluation of cell proliferation. | |||||||||||||
言語 | en | |||||||||||||
学位名 | ||||||||||||||
言語 | ja | |||||||||||||
学位名 | 博士(医学) | |||||||||||||
学位授与機関 | ||||||||||||||
識別子Scheme | kakenhi | |||||||||||||
識別子 | 16201 | |||||||||||||
言語 | ja | |||||||||||||
機関名 | 香川大学 | |||||||||||||
言語 | en | |||||||||||||
機関名 | Kagawa University | |||||||||||||
学位授与年月日 | ||||||||||||||
学位授与年月日 | 2015-06-25 | |||||||||||||
学位授与番号 | ||||||||||||||
学位授与番号 | 甲第614号 | |||||||||||||
権利 | ||||||||||||||
言語 | en | |||||||||||||
権利情報 | Copyright © 2015, Toyota et al.; licensee BioMed Central. | |||||||||||||
権利 | ||||||||||||||
言語 | en | |||||||||||||
権利情報 | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. | |||||||||||||
論文ID(NAID) | ||||||||||||||
識別子タイプ | NAID | |||||||||||||
関連識別子 | 500001356514 | |||||||||||||
PubMed番号 | ||||||||||||||
識別子タイプ | PMID | |||||||||||||
関連識別子 | 25853013 | |||||||||||||
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関連タイプ | isVersionOf | |||||||||||||
識別子タイプ | DOI | |||||||||||||
関連識別子 | https://doi.org/10.1186/s13550-015-0085-3 | |||||||||||||
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関連タイプ | isIdenticalTo | |||||||||||||
識別子タイプ | URI | |||||||||||||
関連識別子 | https://dl.ndl.go.jp/pid/11337517 | |||||||||||||
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関連タイプ | hasVersion | |||||||||||||
識別子タイプ | URI | |||||||||||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4385144/ | |||||||||||||
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出版タイプ | P | |||||||||||||
出版タイプResource | http://purl.org/coar/version/c_fa2ee174bc00049f | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Glioma | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Cell proliferation | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | FLT (fluorothymidine) | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | 4DST (4′-thiothymidine) | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Positron emission tomography | |||||||||||||
KEID | ||||||||||||||
28732 |