WEKO3
アイテム
{"_buckets": {"deposit": "ac56d3cb-e125-426d-81a1-1e25d8293cbc"}, "_deposit": {"created_by": 11, "id": "370", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "370"}, "status": "published"}, "_oai": {"id": "oai:kagawa-u.repo.nii.ac.jp:00000370", "sets": ["40"]}, "author_link": ["1391"], "item_10006_date_granted_11": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2015-09-29"}]}, "item_10006_degree_grantor_9": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "香川大学"}, {"subitem_degreegrantor_language": "en", "subitem_degreegrantor_name": "Kagawa University"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "16201", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_10006_degree_name_8": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)", "subitem_degreename_language": "ja"}]}, "item_10006_description_7": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Abstract\nCholangiocarcinoma is the most common biliary malignancy and the second most common hepatic malignancy after hepatocellular carcinoma (HCC). Galectin-9 (Gal-9) is a tandem-repeat-type galectin that has recently been shown to exert antiproliferative effects on cancer cells. Therefore, the present study evaluated the effects of Gal-9 on the proliferation of human cholangiocarcinoma cells in vitro as well as the microRNAs (miRNAs) associated with the antitumor effects of Gal-9. Gal-9 suppressed the proliferation of cholangiocarcinoma cell lines in vitro and the growth of human cholangiocarcinoma cell xenografts in nude mice. Our data further revealed that Gal-9 increased caspase‑cleaved keratin 18 (CCK18) levels, and the expression of cytochrome c increased in Gal-9-treated cholangiocarcinoma cell lines. These data suggested that Gal-9 induced cholangiocarcinoma cell apoptosis via the intrinsic apoptosis pathway mediated by caspase-dependent or -independent pathways. In addition, Gal-9 reduced the phosphorylation of the epidermal growth factor receptor (EGFR), insulin-like growth factor and insulin-like growth factor-1 receptor (IGF-1R), hepatocyte growth factor receptor and fibroblast growth factor receptor 3 (FGFR3). These findings suggest that Gal-9 can be a candidate of therapeutic target in the treatment of cholangiocarcinoma.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10006_dissertation_number_12": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第616号"}]}, "item_10006_relation_15": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.3892/or.2015.4197", "subitem_relation_type_select": "DOI"}}, {"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://dl.ndl.go.jp/pid/11337522", "subitem_relation_type_select": "URI"}}]}, "item_10006_relation_22": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "26260906", "subitem_relation_type_select": "PMID"}}]}, "item_10006_relation_28": {"attribute_name": "論文ID(NAID)", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "500001356457", "subitem_relation_type_select": "NAID"}}]}, "item_10006_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © Spandidos Publications 2015.", "subitem_rights_language": "en"}]}, "item_10006_text_30": {"attribute_name": "KEID", "attribute_value_mlt": [{"subitem_text_value": "28734"}]}, "item_10006_version_type_18": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_fa2ee174bc00049f", "subitem_version_type": "P"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "Kobayashi, Kiyoyuki", "creatorNameLang": "en"}, {"creatorName": "小林, 聖幸", "creatorNameLang": "ja"}, {"creatorName": "コバヤシ, キヨユキ", "creatorNameLang": "ja-Kana"}], "familyNames": [{"familyName": "Kobayashi", "familyNameLang": "en"}, {"familyName": "小林", "familyNameLang": "ja"}, {"familyName": "コバヤシ", "familyNameLang": "ja-Kana"}], "givenNames": [{"givenName": "Kiyoyuki", "givenNameLang": "en"}, {"givenName": "聖幸", "givenNameLang": "ja"}, {"givenName": "キヨユキ", "givenNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1391", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000319049868", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000319049868"}, {"nameIdentifier": "30769352", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30769352"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-11-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Med_A616.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "本文", "objectType": "fulltext", "url": "https://kagawa-u.repo.nii.ac.jp/record/370/files/Med_A616.pdf"}, "version_id": "9cfe7496-8107-472a-848b-5940a667c772"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-11-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "Med_A616_abstract.pdf", "filesize": [{"value": "95.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 95200.0, "url": {"label": "内容の要旨", "objectType": "abstract", "url": "https://kagawa-u.repo.nii.ac.jp/record/370/files/Med_A616_abstract.pdf"}, "version_id": "99e9dc7a-7c54-486e-bc17-8694e685f9df"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-11-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "Med_A616_result.pdf", "filesize": [{"value": "122.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 122700.0, "url": {"label": "審査の結果の要旨", "objectType": "other", "url": "https://kagawa-u.repo.nii.ac.jp/record/370/files/Med_A616_result.pdf"}, "version_id": "ab1f5828-f331-4c07-a6f0-2134e966a09d"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "cholangiocarcinoma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "galectin-9", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "apoptosis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cell cycle", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "microRNAs", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cytochromec", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "epidermal growth factor receptor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "angio-genesis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest", "subitem_title_language": "en"}]}, "item_type_id": "10006", "owner": "11", "path": ["40"], "permalink_uri": "https://kagawa-u.repo.nii.ac.jp/records/370", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-07-10"}, "publish_date": "2019-07-10", "publish_status": "0", "recid": "370", "relation": {}, "relation_version_is_last": true, "title": ["Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest"], "weko_shared_id": -1}
Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest
https://kagawa-u.repo.nii.ac.jp/records/370
https://kagawa-u.repo.nii.ac.jp/records/3703777340a-224c-40b4-b24a-695f3fe3e001
名前 / ファイル | ライセンス | アクション |
---|---|---|
本文 (1.7 MB)
|
|
|
内容の要旨 (95.2 kB)
|
|
|
審査の結果の要旨 (122.7 kB)
|
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
公開日 | 2019-07-10 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
資源タイプ | doctoral thesis | |||||||||||
アクセス権 | ||||||||||||
アクセス権 | open access | |||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
著者 |
小林, 聖幸
× 小林, 聖幸
WEKO
1391
|
|||||||||||
抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Abstract Cholangiocarcinoma is the most common biliary malignancy and the second most common hepatic malignancy after hepatocellular carcinoma (HCC). Galectin-9 (Gal-9) is a tandem-repeat-type galectin that has recently been shown to exert antiproliferative effects on cancer cells. Therefore, the present study evaluated the effects of Gal-9 on the proliferation of human cholangiocarcinoma cells in vitro as well as the microRNAs (miRNAs) associated with the antitumor effects of Gal-9. Gal-9 suppressed the proliferation of cholangiocarcinoma cell lines in vitro and the growth of human cholangiocarcinoma cell xenografts in nude mice. Our data further revealed that Gal-9 increased caspase‑cleaved keratin 18 (CCK18) levels, and the expression of cytochrome c increased in Gal-9-treated cholangiocarcinoma cell lines. These data suggested that Gal-9 induced cholangiocarcinoma cell apoptosis via the intrinsic apoptosis pathway mediated by caspase-dependent or -independent pathways. In addition, Gal-9 reduced the phosphorylation of the epidermal growth factor receptor (EGFR), insulin-like growth factor and insulin-like growth factor-1 receptor (IGF-1R), hepatocyte growth factor receptor and fibroblast growth factor receptor 3 (FGFR3). These findings suggest that Gal-9 can be a candidate of therapeutic target in the treatment of cholangiocarcinoma. |
|||||||||||
言語 | en | |||||||||||
学位名 | ||||||||||||
言語 | ja | |||||||||||
学位名 | 博士(医学) | |||||||||||
学位授与機関 | ||||||||||||
識別子Scheme | kakenhi | |||||||||||
識別子 | 16201 | |||||||||||
言語 | ja | |||||||||||
機関名 | 香川大学 | |||||||||||
言語 | en | |||||||||||
機関名 | Kagawa University | |||||||||||
学位授与年月日 | ||||||||||||
学位授与年月日 | 2015-09-29 | |||||||||||
学位授与番号 | ||||||||||||
学位授与番号 | 甲第616号 | |||||||||||
権利 | ||||||||||||
言語 | en | |||||||||||
権利情報 | Copyright © Spandidos Publications 2015. | |||||||||||
論文ID(NAID) | ||||||||||||
識別子タイプ | NAID | |||||||||||
関連識別子 | 500001356457 | |||||||||||
PubMed番号 | ||||||||||||
識別子タイプ | PMID | |||||||||||
関連識別子 | 26260906 | |||||||||||
関連サイト | ||||||||||||
関連タイプ | isVersionOf | |||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | https://doi.org/10.3892/or.2015.4197 | |||||||||||
関連サイト | ||||||||||||
関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | URI | |||||||||||
関連識別子 | https://dl.ndl.go.jp/pid/11337522 | |||||||||||
著者版フラグ | ||||||||||||
出版タイプ | P | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_fa2ee174bc00049f | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | cholangiocarcinoma | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | galectin-9 | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | apoptosis | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | cell cycle | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | microRNAs | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | cytochromec | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | epidermal growth factor receptor | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | angio-genesis | |||||||||||
KEID | ||||||||||||
28734 |