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Metformin Inhibits Proliferation and Tumor Growth of QGP-1 Pancreatic Neuroendocrine Tumor Cells by Inducing Cell Cycle Arrest and Apoptosis
https://kagawa-u.repo.nii.ac.jp/records/430
https://kagawa-u.repo.nii.ac.jp/records/4305160a83b-097d-444c-85b5-c61ad343ab17
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本文 (2.0 MB)
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内容の要旨 (382.9 kB)
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審査の結果の要旨 (101.5 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2020-06-01 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Metformin Inhibits Proliferation and Tumor Growth of QGP-1 Pancreatic Neuroendocrine Tumor Cells by Inducing Cell Cycle Arrest and Apoptosis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
山名, 浩喜
× 山名, 浩喜 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background/aim: Pancreatic neuroendocrine tumors (pNETs) are rare pancreatic neoplasms, and therapeutic options for pNETs are limited. Metformin is an anti-hypoglycemic drug that appears to have anticancer effects. However, little is known about the effect of metformin on pNETs. In this study, we investigated the anti-proliferative effect of metformin on a human pNET cell line. | |||||
言語 | en | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Materials and methods: The anti-proliferative properties of metformin were evaluated in QGP-1 and NCI-H727 cells using a cell counting kit-8 assay. Xenograft mouse models were used to assess the tumor effect in vivo. | |||||
言語 | en | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results: Metformin inhibited the proliferation and anti-tumor growth of QGP-1 cells, accompanied by their arrest during the cell cycle at the G0/G1 phase. Immunohistochemical analysis of tumor tissues revealed down-regulation of cyclin D1 and proliferating cell nuclear antigen in the metformin-treated group. Additionally, metformin induced apoptosis, and the expression of survivin and claspin were decreased in metformin-treated QGP-1 cells according to the apoptosis array. Furthermore, the angiogenic related protein TIMP-1 was down-regulated, and its miRNA expression was altered by metformin in QGP-1 cells. | |||||
言語 | en | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusion: Taken together, our study demonstrated the therapeutic potential of metformin and provides molecular mechanistic insights into its anti-tumoral effect on pNETs. This study is the first one describing anti-tumoral effects in pNETs. | |||||
言語 | en | |||||
学位名 | ||||||
言語 | ja | |||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
識別子Scheme | kakenhi | |||||
識別子 | 16201 | |||||
言語 | ja | |||||
機関名 | 香川大学 | |||||
言語 | en | |||||
機関名 | Kagawa University | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2020-03-24 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第743号 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. | |||||
権利 | ||||||
言語 | ja | |||||
権利情報 | エンバーゴ期間満了。 / The embargo period has expired. | |||||
論文ID(NAID) | ||||||
識別子タイプ | NAID | |||||
関連識別子 | 500001384959 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 31892560 | |||||
関連サイト | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.21873/anticanres.13933 | |||||
関連サイト | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | URI | |||||
関連識別子 | https://dl.ndl.go.jp/pid/11511509 | |||||
著者版フラグ | ||||||
出版タイプ | P | |||||
出版タイプResource | http://purl.org/coar/version/c_fa2ee174bc00049f | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Pancreatic neuroendocrine tumor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | apoptosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cell cycle | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | metformin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | microRNA | |||||
KEID | ||||||
28990 |