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Diagnostic significance of apical membranous and cytoplasmic dot-like CD26 expression in encapsulated follicular variant of papillary thyroid carcinoma : a useful marker for capsular invasion
https://kagawa-u.repo.nii.ac.jp/records/7335
https://kagawa-u.repo.nii.ac.jp/records/733522ff6f4a-6082-424e-bf1a-2c58a11622e8
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2021-04-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Diagnostic significance of apical membranous and cytoplasmic dot-like CD26 expression in encapsulated follicular variant of papillary thyroid carcinoma : a useful marker for capsular invasion | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | 被包性濾胞型乳頭癌におけるCD26の細胞膜発現およびドット状発現の診断意義 : 被膜浸潤の有用なマーカー | |||||
言語 | ja | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
髙木, 翔士
× 髙木, 翔士 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and invasive encapsulated follicular variant of papillary thyroid carcinoma (EFV-PTC) are indistinguishable preoperatively. CD26 expression in follicular tumor-uncertain malignant potential (FT-UMP) is reported to be clearly higher than in that without capsular invasion. To verify the diagnostic significance of CD26 immunostaining in EFV-PTC, we examined the expression pattern of CD26 in non-invasive EFV-PTC (NIFTP) and invasive EFV-PTC. We performed immunohistochemical analysis using CD26 antibody for 37 NIFTPs and 54 EFV-PTCs (34 minimally invasive EFV-PTCs and 20 widely invasive EFV-PTCs). Most NIFTP samples showed an apical membranous pattern or a cytoplasmic diffuse pattern of expression. Invasive EFV-PTCs more frequently showed a cytoplasmic dot-like pattern, and the labeling indices of tumor cells with cytoplasmic dot-like patterns were significantly higher than those in NIFTPs. The sizes of dots seen in NIFTPs (mean: 1.12 μm) were significantly smaller than in invasive EFV-PTCs (1.33 μm), minimally invasive EFV-PTC (1.27 μm), and widely invasive EFV-PTC (1.38 μm). We, therefore, conclude that cytoplasmic diffuse and/or cytoplasmic dot-like CD26 expression, particularly the larger CD26-positive dots, could be useful markers for capsular invasion in EFV-PTC. CD26 immunostaining, using cell blocks or cytological specimens, may preoperatively distinguish between NIFTP and invasive EFV-PTC. | |||||
言語 | en | |||||
学位名 | ||||||
言語 | ja | |||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
識別子Scheme | kakenhi | |||||
識別子 | 16201 | |||||
言語 | ja | |||||
機関名 | 香川大学 | |||||
言語 | en | |||||
機関名 | Kagawa University | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2021-03-24 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第769号 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © The Japan Endocrine Society | |||||
関連サイト | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1507/endocrj.EJ19-0501 | |||||
著者版フラグ | ||||||
出版タイプ | P | |||||
出版タイプResource | http://purl.org/coar/version/c_fa2ee174bc00049f | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Follicular variant of papillary thyroid carcinoma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | CD26 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Capsular invasion |