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Assessment of sensory perception and processing using current perception threshold in Parkinson's disease
https://kagawa-u.repo.nii.ac.jp/records/194
https://kagawa-u.repo.nii.ac.jp/records/194ede645b1-b48e-42a9-b5f7-7ea6378401ea
| 名前 / ファイル | ライセンス | アクション |
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内容の要旨 (235.7 kB)
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審査の結果の要旨 (317.1 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2013-12-26 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Assessment of sensory perception and processing using current perception threshold in Parkinson's disease | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| 著者 |
池田, 和代
× 池田, 和代
WEKO
2076
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Aim Although peripheral deafferentation is one of the causes of abnormal sensory processing in Parkinson's disease (PD), functional assessment of different‐size sensory nerve populations remains insufficient. We assessed the characteristics of sensory perception and processing in PD patients using current perception threshold (CPT). |
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| 言語 | en | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Methods A total of 28 patients with PD, 20 with multiple system atrophy (MSA) and 28 healthy controls underwent CPT examination using a Neurometer device, which can selectively stimulate A‐β fibers at 2000 Hz, A‐δ fibers at 250 Hz and C fibers at 5 Hz. |
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| 言語 | en | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Results Significant differences in CPT for all stimulus frequencies were observed among the three groups. PD patients had significantly higher CPT for all stimulus frequencies than control individuals (P < 0.05). Also, PD patients had significantly higher CPT for 250 and 5 Hz than MSA patients (P < 0.05). At the optimum cut‐off level, the CPT distinguished PD patients from MSA patients with a high sensitivity (82% at 250 Hz, 86% at 5 Hz) and specificity (75% at 250 Hz, 80% at 5 Hz). The CPT were not affected by clinical profile, cardiac sympathetic denervation or cardiovascular autonomic dysfunction. |
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| 言語 | en | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Conclusion Significantly increased CPT in PD indicate altered processing of sensory information involving A‐β, A‐δ and C fibers. The clear distinction of CPT between PD and MSA might reflect the involvement in small fiber dysfunction in PD, but not in MSA. These findings suggest that CPT testing might contribute to diagnosis of PD, as well as the understanding of sensory processing involving peripheral deafferentation. |
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| 言語 | en | |||||||||||
| 学位名 | ||||||||||||
| 言語 | ja | |||||||||||
| 学位名 | 博士（医学） | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 16201 | |||||||||||
| 言語 | ja | |||||||||||
| 学位授与機関名 | 香川大学 | |||||||||||
| 言語 | en | |||||||||||
| 学位授与機関名 | Kagawa University | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2013-12-26 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第579号 | |||||||||||
| 権利 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報 | © 2013 Japanese Society of Neurology and Wiley Publishing Asia Pty Ltd | |||||||||||
| 関連サイト | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1111/ncn3.55 | |||||||||||
| 助成情報 | ||||||||||||
| 助成機関識別子タイプ | Crossref Funder | |||||||||||
| 助成機関識別子 | https://doi.org/10.13039/501100001691 | |||||||||||
| 助成機関名 | 日本学術振興会 | |||||||||||
| 言語 | ja | |||||||||||
| 助成機関名 | Japan Society for the Promotion of Science | |||||||||||
| 言語 | en | |||||||||||
| 研究課題番号URI | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591297/ | |||||||||||
| 研究課題番号 | 24591297 | |||||||||||
| 研究課題名 | 近赤外線分光法および電流知覚閾値を用いた新しいパーキンソン病診断法の開発 | |||||||||||
| 言語 | ja | |||||||||||
| 研究課題名 | Development of novel diagnostic methods for Parkinson's disease. | |||||||||||
| 言語 | en | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | current perception threshold | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | epidermal nerve fiber | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | multiple system atrophy | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Parkinson's disease | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | sensory processing | |||||||||||
| KEID | ||||||||||||
| 値 | 27462 | |||||||||||
