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Cerebral blood volume measurement using near-infrared time-resolved spectroscopy and histopathological evaluation after hypoxic-ischemic insult in newborn piglets
https://kagawa-u.repo.nii.ac.jp/records/348
https://kagawa-u.repo.nii.ac.jp/records/3486c527a28-3717-4ffb-9ff1-0a3f600685ac
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本文 (3.1 MB)
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内容の要旨 (166.6 kB)
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審査の結果の要旨 (124.0 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2019-03-22 | |||||
| タイトル | ||||||
| タイトル | Cerebral blood volume measurement using near-infrared time-resolved spectroscopy and histopathological evaluation after hypoxic-ischemic insult in newborn piglets | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
中村, 信
× 中村, 信 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract The aim of this study was to assess the relationship between the cerebral blood volume (CBV) measured by near‐infrared time‐resolved spectroscopy (TRS) and pathological change of the brain in a hypoxic‐ischemic (HI) piglet model. Twenty‐one anesthetized newborn piglets, including three sham controls, were studied. An HI event was induced by low inspired oxygen. CBV was measured using TRS (Hamamatsu TRS‐10). Data were collected before, during, and 6 h after the insult. CBV was calculated as the change from the end of the insult. The piglets were allowed to recover from anesthesia for 6 h after the insult. At the age of 5 days, the brains of the piglets were perfusion‐fixed, and histologic evaluations of brain tissue were performed. The extent of histopathological damage was graded in 0.5‐unit intervals on a 9‐step scale. CBV increments were well correlated with histopathological scores, especially at 1 and 3 h after resuscitation. Spearman's rank‐correlation coefficients at 1, 3, and 6 h after resuscitation in the gray matter were 0.9016, 0.9127, and 0.6907, respectively. We conclude that an increased CBV after HI insult indicates more marked histological brain damage. CBV measurement immediately after resuscitation provides a more precise prediction of the histological outcome. |
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| 言語 | en | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 16201 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 香川大学 | |||||
| 言語 | en | |||||
| 学位授与機関名 | Kagawa University | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2015-06-25 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第613号 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | Copyright © 2015 ISDN | |||||
| 権利 | ||||||
| 言語 | ja | |||||
| 権利情報 | この博士論文の本文については、次のエルゼビアの著作権ポリシーの規定により公開しています。「博士論文の場合は、エンバーゴ期間に関係なく機関リポジトリに出版社版を公開することができます。」 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | The text of this doctoral dissertation is published according to the following Elsevier copyright policy. "In the case of doctoral dissertations, publishers can be published in institutional repositories regardless of the Embargo period." | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | Copyright © 2015 Elsevier Ltd. All rights reserved. | |||||
| 論文ID（NAID） | ||||||
| 識別子タイプ | NAID | |||||
| 関連識別子 | 500001345113 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 25702525 | |||||
| 関連サイト | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.ijdevneu.2015.02.009 | |||||
| 関連サイト | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://dl.ndl.go.jp/pid/11278721 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | P | |||||
| 出版タイプResource | http://purl.org/coar/version/c_fa2ee174bc00049f | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Amplitude‐integrated electroencephalography | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Animal model | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Brain histology | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cerebral blood volume | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Near‐infrared spectroscopy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Hypoxia‐ischemia | |||||
| KEID | ||||||
| 値 | 28613 | |||||
