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Role of Mir-452-5p Overexpression in Epithelial–Mesenchymal Transition (EMT) in Early-stage Colorectal Cancer
https://kagawa-u.repo.nii.ac.jp/records/2000125
https://kagawa-u.repo.nii.ac.jp/records/200012567f0f301-9e7c-4995-8128-dce46360b77b
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2023-12-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Role of Mir-452-5p Overexpression in Epithelial–Mesenchymal Transition (EMT) in Early-stage Colorectal Cancer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
小山, 裕紀子
× 小山, 裕紀子 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background/aim: The microRNA miR-452-5p holds a critical role in the progression of multiple tumor formations, but there is limited understanding regarding the epithelial-mesenchymal transition (EMT) progression and its underlying mechanisms in the early-stage colorectal cancer (CRC). We aimed to explore the change in miRNA expression in early-stage CRC and examine the role of these miRNAs in CRC. | |||||
言語 | en | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Materials and methods: The expression levels of miR-452-5p in tissues and cells of early-stage CRC were determined by real-time quantitative polymerase chain reaction. Additionally, the biological effects of miR-452-5p on CRC were investigated by in vitro functional experiments. | |||||
言語 | en | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results: The expression levels of miR-452-5p were found increased in early-stage CRC tissue. We found that miR-452-5p promoted CRC cell proliferation but inhibited epithelial-mesenchymal transition. Furthermore, miR-452-5p promoted cell proliferation through activation of the extracellular signal-regulated kinase pathway, and inhibited cell invasion through suppression of Slug (Snail2) expression and up-regulation of E-cadherin expression. | |||||
言語 | en | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusion: The expression of miR-452-5p is up-regulated in early CRC and suppresses epithelial-mesenchymal transition in CRC. These discoveries suggest that miR-452-5p has the potential to serve as a viable therapeutic target for CRC. | |||||
言語 | en | |||||
学位名 | ||||||
言語 | ja | |||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
識別子Scheme | kakenhi | |||||
識別子 | 16201 | |||||
言語 | ja | |||||
機関名 | 香川大学 | |||||
言語 | en | |||||
機関名 | Kagawa University | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2023-12-26 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第845号 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0) | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 37652512 | |||||
関連サイト | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.21873/invivo.13295 | |||||
関連サイト | ||||||
関連タイプ | hasVersion | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10500504/ | |||||
助成情報 | ||||||
識別子タイプ | Crossref Funder | |||||
助成機関識別子 | https://doi.org/10.21873/invivo.13295 | |||||
助成機関名 | 日本学術振興会 | |||||
言語 | ja | |||||
助成機関名 | Japan Society for the Promotion of Science | |||||
言語 | en | |||||
研究課題番号URI | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K15646/ | |||||
研究課題番号 | 21K15646 | |||||
研究課題名 | 早期大腸癌に特異的なmicroRNAの同定とその機能解析 | |||||
言語 | ja | |||||
助成情報 | ||||||
助成機関名 | 香川大学医学部医学科同窓会讃樹會 | |||||
言語 | ja | |||||
助成機関名 | Alumni Association Sanjukai, Kagawa University Faculty of Medicine | |||||
言語 | en | |||||
研究課題番号 | R3-2 | |||||
研究課題名 | 早期大腸癌に特異的なmicroRNAの同定とその機能解析 | |||||
言語 | ja | |||||
著者版フラグ | ||||||
出版タイプ | P | |||||
出版タイプResource | http://purl.org/coar/version/c_fa2ee174bc00049f | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Colorectal cancer | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | miR-452-5p | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | epithelial–mesenchymal transition |