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D-allose attenuates overexpression of inflammatory cytokines after cerebral ischemia/reperfusion injury in gerbil
https://kagawa-u.repo.nii.ac.jp/records/268
https://kagawa-u.repo.nii.ac.jp/records/26847534e1a-0fa5-441d-bab1-0b08a1e227b7
名前 / ファイル | ライセンス | アクション |
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本文 (371.5 kB)
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内容の要旨 (72.0 kB)
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審査の結果の要旨 (446.2 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2017-08-21 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | D-allose attenuates overexpression of inflammatory cytokines after cerebral ischemia/reperfusion injury in gerbil | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
篠原, 奈都代
× 篠原, 奈都代 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background The present study investigates the effects of d-allose, a rare sugar, on the inflammatory response after transient forebrain ischemia in the gerbil and whether it reduces oxidative stress (8-hydroxyl-2′-deoxyguanosine levels) and behavioral deficits. |
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言語 | en | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Methods Transient forebrain ischemia was induced by occlusion of the bilateral common carotid arteries for 5 minutes. d-Allose was intraperitoneally injected immediately after ischemia (400 mg/kg). Inflammatory cytokines and oxidative damage in the hippocampus and behavioral deficits were examined 3 days after ischemia. |
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言語 | en | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results d-Allose administration reduced ischemia-induced cytokine production, oxidative stress, and behavioral deficits (motor and memory related). |
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言語 | en | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusions The present results suggest that d-allose reduces brain injury after transient global ischemia by suppressing inflammation as well as by inhibiting oxidative stress. |
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言語 | en | |||||
学位名 | ||||||
言語 | ja | |||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
識別子Scheme | kakenhi | |||||
識別子 | 16201 | |||||
言語 | ja | |||||
機関名 | 香川大学 | |||||
言語 | en | |||||
機関名 | Kagawa University | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-06-28 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第643号 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | Copyright © 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved. | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This article is provided in the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (CC-BY-NC-ND 4.0) .https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | |||||
論文ID(NAID) | ||||||
識別子タイプ | NAID | |||||
関連識別子 | 500001039463 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 27342700 | |||||
関連サイト | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.01.030 | |||||
関連サイト | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | URI | |||||
関連識別子 | https://dl.ndl.go.jp/pid/10952393 | |||||
著者版フラグ | ||||||
出版タイプ | P | |||||
出版タイプResource | http://purl.org/coar/version/c_fa2ee174bc00049f | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Ischemia | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cytokines | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | d-allose | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | hyperactivity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | inflammation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | oxidation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | reperfusion | |||||
KEID | ||||||
27869 |